I was diagnosed with Addison's about a year ago and was started on 40mg of hydrocortisone. I have gradually weaned myself down to 25mg, but my endo would like me to get it down to 10 -15 mg per day. I have found this impossible and went searching for something that might help. After have done some thorough research into pregnenolone - the most use useful being your site - I figured there might be a chance it would let me reduce my hydrocorisone. I have been taking 10mg no more than two days in a row, with at least one day between doses, sometimes much longer. The effects are almost instant. I can take 20 mg of hydrocortisone and not only feel fine but have a much enhanced sense of well-being, energy, focus, ability to plan and cope with stress. It also gives me a very slight rise in libido - and I've had no libido whatsoever for a decade or so, so this is significant. I would suggest proceeding extremely cautiously, but occasional use of pregnenolone might be a good alternative to DHEA for some. I also feel no sense of withdrawal on the days I don't take it. See http://www.raysahelian.com/pregnenolone.html