Oncologists at Columbia University Medical Center in New York randomly assigned 50 children with acute lymphoblastic leukemia to take either milk thistle capsules or placebo capsules for four weeks while undergoing their "maintenance" round of chemotherapy. At the start of the study, all of the children had signs of liver inflammation from their previous round of treatment. After one month, children taking milk thistle had lower levels of two liver enzymes that show liver damage than those in the placebo group. Children on milk thistle were also somewhat less likely to need their chemotherapy dose lowered at any point. See http://www.raysahelian.com/milkthistle.html