Patients with type 2 diabetes are under high oxidative stress. The objective of this Italian study was to evaluate the benefit of L-carnitine on the reduction of oxidized LDL cholesterol in patients with type 2 diabetes. Eighty-one patients with diabetes were randomly assigned to 1 of 2 treatment groups for 3 months. The 2 groups received either 2 g L-carnitine once daily or placebo. At the end of the study period, the L-carnitine-treated patients showed significant improvements compared with the placebo group. The following decreased: oxidized LDL levels; LDL cholesterol; triglycerides; and apolipoprotein A1 concentrations.Carnitine appears to be an additional supplement to be potentially beneficial in those who have diabetes. A dosage of 250 mg a day or 500 mg three times a week is a good options. See http://www.raysahelian.com/carnitine.html